Search on:
VINCA ALKALOIDS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Vinca Alkaloids
Descriptor
Spanish
:
Alcaloides de la Vinca
Descriptor
Portuguese
:
Alcaloides de Vinca
Synonyms
English
:
Alkaloids, Vinca
Tree Number:
D03.132.436.681.827
D03.633.100.473.402.681.827
Definition
English
:
A group of indole-indoline dimers which are
ALKALOIDS
obtained from the VINCA genus of
plants
. They inhibit
polymerization
of
TUBULIN
into
MICROTUBULES
thus blocking spindle formation and arresting cells in
METAPHASE
. They are some of the most useful
ANTINEOPLASTIC AGENTS.
Pharmacological Action:
Antineoplastic Agents
Tubulin Modulators
History Note
English
:
73
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
15153
Unique Identifier:
D014748
Occurrence in VHL
:
Similar:
DeCS